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KMID : 1145520170030020065
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Journal of Radiopharmaceuticals and Molecular Probes
2017 Volume.3 No. 2 p.65 ~ p.71
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Effect of filters and reconstruction method on Cu-64 PET image
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Lee Seon-Hwa
Kim Jung-Min
Kim Jung-Young
Kim Jin-Su
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Abstract
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To assess the effects of filter and reconstruction of Cu-64 PET data on Siemens scanner, the various reconstruction algorithm with various filters were assessed in terms of spatial resolution, non-uniformity (NU), recovery coefficient (RC), and spillover ratio (SOR). Image reconstruction was performed using filtered backprojection (FBP), 2D ordered subset expectation maximization (OSEM), 3D reprojection algorithm (3DRP), and maximum a posteriori algorithms (MAP). For the FBP reconstruction, ramp, butterworth, hamming, hanning, or parzen filters were used. Attenuation or scatter correction were performed to assess the effect of attenuation and scatter correction. Regarding spatial resolution, highest achievable volumetric resolution was 3.08 mm3 at the center of FOV when MAP (ß=0.1) reconstruction method was used. SOR was below 4% for FBP when ramp, Hamming, Hanning, or Shepp-logan filter were used. The lowest NU (highest uniform) after
attenuation & scatter correction was 5.39% when FBP (parzen filter) was used. Regarding RC, 0.9 < RC < 1.1 was obtained when OSEM (iteration: 10) was used when attenuation and scatter correction were applied. In this study, image quality of Cu-64 on Siemens Inveon PET was investigated. This data will helpful for the quantification of Cu-64 PET data.
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KEYWORD
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Cu-64, filter, reconstruction, Inveon PET
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